11. DiaSorin — Luminex — $1.8B

Luminex develops diagnostic testing products, including platforms based on multiplexing technology. The Austin, Texas-based company’s diagnostics include COVID-19 tests, which received FDA emergency use authorization last year.

12. Roche — GenMark Diagnostics — $1.8B

Roche (SWX: RO, ROG) looks to bolster its molecular diagnostics portfolio with GenMark Diagnostics’ (NSDQ:GNMK) syndromic panel testing portfolio. The ePlex system made by GenMark drives efficiency in the laboratory through a streamlined order-to-reporting workflow, enabling rapid diagnoses.

13. Boston Scientific — Baylis Medical — $1.75B

Boston Scientific (NYSE:BSX) expanded its electrophysiology and structural heart product portfolios to include the radiofrequency (RF) NRG and VersaCross transseptal platforms from Baylis Medical, as well as a family of guidewires, sheaths and dilators used to support left heart access.

14. GE Healthcare — BK Medical — $1.45B

GE Healthcare (NYSE:GE) made a major imaging play by acquiring BK Medical and its intraoperative imaging and surgical navigation technology for guiding clinicians during minimally invasive and robotic surgeries. The platform also aids in visualizing deep tissue during procedures in neuro and abdominal surgery and in ultrasound urology.

15. Boston Scientific — Preventice Solutions — $1.225B

Another of several big-time M&A plays by Boston Scientific (NYSE:BSX), the company bought Preventice and its mobile health solutions and remote monitoring offerings for patients with cardiac arrhythmias. Among its products are wearables, including the PatientCare platform and BodyGuardian family of monitors.

16. Philip Morris — Vectura — $1.2B

In one of the more controversial moves of 2021, Philip Morris (NYSE:PM), a cigarette maker, bought Vectura to gain access to the company’s inhaled drug delivery technologies that can help it reach its goal of generating more than 50% of its total net revenue from smoke-free products by 2025.

17. Medtronic — Intersect ENT — $1.1B

By acquiring Intersect ENT (NSDQ:XENT), medtech giant Medtronic (NYSE:MDT) expanded its portfolio of ear, nose and throat medical devices. Intersect ENT makes the Propel and Sinuva sinus implants that open sinus passageways to deliver an anti-inflammatory steroid to aid in healing.

18. Boston Scientific — Lumenis — $1.1B

In the third and final appearance of Boston Scientific (NYSE:BSX) on this list, the company picked up Lumenis and its surgical business, which includes premier energy-based laser systems, fibers and accessories for urology and otolaryngology procedures.

19. Adapt Health — AeroCare — $1.1B

AeroCare develops technology-enabled respiratory and home medical equipment distribution platforms in the U.S., including direct-to-patient equipment and services like CPAP and BiPAP machines, oxygen concentrators, home ventilators and other durable medical equipment products.

20. Dentsply Sirona — Byte — $1.04B

The earliest major acquisition of 2021, Dentsply Sirona’s (NSDQ:XRAY) Jan. 5 announcement confirmed that the buy will utilize Byte’s leadership position in the direct-to-consumer clear aligner market.