Sino Biological

The baculovirus–insect cell expression system—insect cells used in conjunction with the baculovirus expression vector system (BEVS)—remains a crucial technology for manufacturing large and complex proteins. This eukaryotic expression system offers inherent safety, ease of scale-up, flexible product design, and versatility for a broad range of proteins. As artificial intelligence and computational technologies advance, aiding in the design of complex protein structures with potential folding challenges, baculovirus–insect cell expression systems will remain essential in facilitating the development and production of innovative medicines to meet unmet patient needs. Sino Biological is significantly expanding in the United States and improving baculovirus–insect cell expression offerings at its Houston, Texas, facility, the Center for Bioprocessing.

Advantages of Baculovirus–Insect Cell Expression Systems

The baculovirus–insect cell expression system is a …

Introduction Since the approval of Orthoclone OKT3 in 1986, more than 100 monoclonal antibodies (mAbs) have been approved by the Food and Drug Administration (FDA) to treat a variety of diseases ranging from autoimmune disorders, infectious diseases, and cancer [1-2]. In the context of the current COVID-19 pandemic, it’s crucial that these biologics are developed rapidly and efficiently. Among various antibody discovery approaches, including hybridoma technology, single B cell screening is a powerful and efficient strategy for generating antigen-specific mAbs based on the direct amplification of the VH and VL regions encoding genes from single B cells [3-4]. Notably, single B cell screening has various advantages that include maintaining the naïve VH/VL pairing, requiring relatively few cells, and the ability to discover antibodies against challenging targets.

Single B Cell Screening Technologies Single B cell screening technologies have emerged and evolved rapidly ov…