La Jolla, Calif.–based Tryp (CSE: TRYP) is tapping the University of Michigan to test its TRP-8803 drug formulation against traditional oral formulations of synthetic psilocybin.
The psilocybin-based drug developer will also work with the university to compare TRP-8803 with conventional formulations of synthetic psilocybin. In particular, the university will perform pharmacokinetic analysis for blood samples from patients who received psilocybin via oral and novel delivery methods.
Additionally, Tryp expects the partnership with the University of Michigan to help advance TRP-8803 to Phase 2b clinical trials. The research alliance will explore the psilocybin-induced increase in neurophysiological complexity and psilocybin’s potential to reduce chronic central pain. The University of Michigan also will explore the impact of alternative delivery strategies of psilocybin on pain indices and insular glutamate and gamma-aminobutyric acid (GABA) levels.