Ultrasound research with rats shows potential for depression therapy

[Photo by Sibya via Pixabay]

Ultrasound-based medical devices may have potential as noninvasive treatment for depression and other mental health issues, according to new research from Tokyo University of Science and Fujimic.

Knowing that whole-body exposure to high-frequency ultrasound increases human brain activity, they used rats — which enjoy high-frequency ultrasound vocalizations (USV) — to explore ultrasonic effects of the mechanisms underlying depression.

Researchers used rats, including some without olfactory lobes (organs that regulate neurotransmission), to study agitation and anxiety-like behavior. with and without exposure to USV for 24 hours. Olfactory bulbectomized (OB) rats were used because they experience changes in neurotransmitters, endocrine secretions and behavior similar to humans with depression.

“Since studies on ultrasound exposure have been primarily conducted on hu…

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