Roche’s focus spans oncology, immunology, neuroscience, and cardiovascular diseases. The company’s oncology portfolio stands out with candidates such as inavolisib and giredestrant that target novel mechanisms in breast cancer. Additionally, Inavolisib, a PI3K inhibitor, targets the PI3Kα isoform, involved in the pathways that drive cell growth and survival. It shows potential not only in breast cancer but also i…
Could LSD change the game in anxiety treatment?
A once-controversial psychedelic substance could hold the key to treating Generalized Anxiety Disorder (GAD). This is the view of Dr. Rakesh Jain, a prominent psychiatrist who serves as a clinical professor at the Department of Psychiatry at Texas Tech University School of Medicine. While ack…
Are Big Pharma giants getting the right ROI on their R&D investments? A visual exploration
In raw numbers, R&D spending in the pharmaceutical industry has surged over the past few decades, jumping from about $30 billion across the industry to more than $200 billion annually by the 2020s. Despite record-breaking R&D spending hitting $161 billion in 2023, marking a nearly 50% increase since 2018, as IQVIA has noted, …
Moving the needle on diversity in clinical trials: Where do we go from here?
As a result, the U.S. government has taken increased measures with the passage of the Food and Drug Omnibus Report Act of 2022 (FDORA), which will require sponsors to submit diversity plans to the U.S. Food and Drug Administration (FDA) for all late-stage st…
From gatekeeper to strategist: The evolution of the CISO role in drug development
But that image is outdated — especially in risk-focused industries like financial services where CISOs are integral to digital transformation projects and the broader risk management considerations.
From CIS-‘no’ to risk maestro“Drug development is a risk-focused industry as well,” said Daniel Ayala, chief security and trust officer for Dotmatics. “There is a huge amount of risk.” Consequently, CISOs working in pharma contexts are increasingly expanding their roles from technical experts to risk-aware business leaders who happen to have deep technical expert…
Off with the training wheels: AI-based patient characterization can improve clinical trial performance without large data sets
Artificial intelligence (AI) holds great promise in improving this success rate by providing data-driven approaches to identifying traits and their combinations that enable more effective paradigms to enrich patien…
Rice Biotech Launch Pad plans to make Houston a top-tier biotech hub
Houston, the nation’s fourth largest city, has not traditionally been a leader in biotechnology, but Rice University’s new Rice Biotech Launch Pad aims to change that. As Omid Veiseh, director of the Launch Pad, explains, “What we wanted with the Launch Pad was something different.” The goal is to capitalize on Rice’s research strengths and the vast medical expertise at the nearby Texas Medical Center.
Ho…Could an ‘extreme’ hibernating ground squirrel unlock new obesity treatments?
In the hunt for the next obesity blockbuster, both Lilly and Novo Nordisk are turning to Fauna Bio’s expertise in extreme mammal genomics. Among Fauna Bio’s focus areas is the 13-lined ground squirrel, an example of the company’s emphasis on “extreme mammals.” The squirrels are known for their remarkable metabolic transformations during hibernation that make them…
Biotech bounces back at JPM 2024 on optimism, breakthroughs and calculated bets, but uncertainties persist
“I feel like in the last two or three weeks, we’ve almost made up for 50% of the deals that didn’t happen in 2023,” quipped Jen Nwankwo, CEO of 1910 Genetics, a company specializing in computational biology and automated laboratory technologies. Pointing to recent clinical successes and FDA approva…
Core trends in 2023 FDA drug approvals: Oncology, neurology and hematology dominate
2023 was a big year for hematology, neurology and oncology, with the medical specialties seeing the most FDA approvals. In terms of sponsors, Pfizer had the most approvals with six total, followed by UCB and Chiesi, each with three apiece.
When looking at commercial prospects, AstraZeneca’s respiratory syncytial virus antibody Beyfortus could be the biggest blockbuster from the 2023 cohort with expected peak sales of $1.9 billion. Alzheimer’s drug Leqembi could also be a major success, making up for the tepid demand for Aduhelm, which won conditional approval in 2021. While Aduhelm’s sales have sputtered, Leqembi could see peak revenue of $4.8 billion according to analysts.
Oncology continues to be a hot specialty with the most competition among the newly approved drugs, as the FDA continues to green light new entrants in crowded target classes such as PD-1 inhibitors.
google.charts.load('current', { 'p…How a J&J exec found her calling in autoantibody drug development
Dr. Katie Abouzahr’s career, which began in the wards of the UK’s National Health Service (NHS) before extending into management consulting, paved the way for her leadership of autoantibody and maternal fetal medicine programs at Johnson & Johnson. “It’s not a typical pharma executive’s straight line path,” she acknowledged. “Careers can often be jungle gyms as opposed to ladders that you climb one rung at a time. It’s always a mixture of opportunity, timing, serendipity, and persistence.”
Those qualities helped pave the way for her current focus on autoantibody-based conditions marked by high unmet need. Drawing on her experience across clinical medicine, consulting, and drug development, Abouzahr focuses on advancing medicines for autoimmune and autoantibody-driven diseases, which are marked by high unmet need. The broader immunology area is a central …
Unlocking generative AI requires reshaping culture, operations, and talent dynamics
But deploying such tools at scale requires a mix of strategic thinking, curiosity and new approaches to cultivating talent. As we enter 2024, life science organizations must rethink their approach to ad…