Molecular photoswitches: Illuminating the future of inherited retinal disease treatment

A retina model cross-section labeled with antibodies against recoverin (green), calretinin (red) and PKA (blue). [NIH]

Vision, one of our most valued senses, is a complex orchestration of light-sensing photoreceptors, neurons, and intricate pathways leading to the brain. Central to this native biological system are the photoreceptors – the rods and cones – cells that are responsible for capturing light and initiating visual perception. For many with inherited retinal diseases (IRDs), the degradation of these photoreceptors represents an inevitable descent into darkness. Enter molecular photoswitches, a new class of small molecules poised to revolutionize the field of ophthalmology. Notably, preliminary data coming out of phase 1b clinical trial demonstrates the feasibility of restoring vision for those suffering from inherited retinal disease. 

Understanding Molecular Photoswitches

In healthy eyes, rods and cone…

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