Insilico Medicine wins IND approval for AI-designed USP1 inhibitor for cancer trials in U.S. and China

Insilico Medicine has made a significant breakthrough with its AI-designed USP1 inhibitor, ISM3091. The US Food and Drug Administration (FDA) has accepted Insilico’s Investigational New Drug (IND) application for this promising drug, marking a significant milestone for AI-assisted drug discovery.

“The FDA’s acceptance of our IND for ISM3091 signifies that the FDA recognizes its potential value, and we can now open clinical trial sites across multiple centers and begin to study ISM3091 in human patients who may benefit from novel therapies,” said Dr. Sujata Rao, senior vice president, head of global clinical development at Insilico Medicine.

The company’s discovery and development of drug candidates, including ISM3091 and ISM001-055, which has also progressed to the clinic, showcases the efficiency and cost-effectiveness of AI in accelerating drug development. ISM001-055, a potentially first-in-class small molecule inhibitor for idiopathi…

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