A new microparticle approach may offer hope for reversing multiple sclerosis

MRI image of a brain hemisphere from a multiple sclerosis patient, false-colored to highlight affected areas. Credit: Govind Bhagavatheeshwaran and Daniel Reich at NIH.

Johns Hopkins researchers have made strides in a study focusing on multiple sclerosis. By applying microparticles to activate regulatory T cells, they were able to reverse MS-like symptoms in mice.

There currently is no cure for multiple sclerosis (MS). But a recent study by Johns Hopkins Medicine shows encouraging progress towards that goal: They have demonstrated the ability to reverse, and in many instances, entirely mitigate symptoms similar to multiple sclerosis in mice.

The study, published in the peer-reviewed journal Science Advances, found a reversal of the MS-like symptoms in 100% of the mice. A total of 38% achieved a full recovery. In the study, many of the mice that received tolerogenic microparticles (Tol-MPs) displayed s…

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