Lung-on-chip predicts COVID-19 antiviral response

While vaccines have emerged as a central tool in battling the COVID-19 pandemic, the SARS-CoV-2 virus continues to fuel waves of infections. 

COVID-19 antivirals could play a vital role in managing the disease in the future, and a handful are currently in use in the U.S. 

One possible way to accelerate the development of additional antivirals for COVID-19 and other respiratory viral infections is the availability of more accurate preclinical models. 

The nonprofit engineering innovation company Draper has released a study showing the power of combining human tissue models based on an organ-on-chip platform in a dynamic tissue microenvironment with input from microbiologists and bioengineers. 

In essence, the Cambridge, Massachusetts–based company has developed a human lung model known as PREDICT96-ALI that can gauge the efficacy of SARS-CoV-2 drugs, including antivirals. 

In the research published on the pre-print server bioRxiv, researcher…

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