Advances in RORγt inhibition: Selective targeting of IL-17 producing cells while maintaining proper thymocyte maturation

Retinoic acid receptor-related orphan receptor gamma t (RORγt) inhibitors are currently in development for various indications. RORγt plays a crucial role in driving T helper 17 (Th17) differentiation and interleukin 17 (IL-17) expression. In homeostasis, these cells play a vital role in the defense against bacteria and fungi. However, this cell type seems to be dysregulated in many autoimmune diseases such as psoriasis, multiple sclerosis and others. In recent years, the focus has been on psoriasis, but other autoimmune and inflammatory diseases such as chronic obstructive pulmonary disease (COPD), inflammatory bowel disease (IBD) and dry eye disease are also of interest. Finally, one study is being conducted on castration-resistant prostate cancer.

The nuclear receptor RORγt

RORγt is the shorter isoform of the retinoic acid receptor-related orphan receptor gamma (RORγ, NR1F3). It belongs to the nuclear receptor (NR) superfamily, discovered in 1998, about four years …

Read more
  • 0