Flow chemistry image courtesy of Vernalis Research
Flow chemistry is a growing technology in the pharma industry, where it has proved itself invaluable, especially in the process development phase of drug discovery. However, the hit-to-lead generation phase of drug discovery has been slower to embrace these techniques. Nevertheless, the potential benefits are huge, particularly for rapid library generation and challenging chemistries that were previously hard to achieve by traditional batch methods. This article looks at how finding a groundbreaking flow chemistry application led to the wider adoption of flow chemistry in synthesis at a small pharma company.
The pharma industry frequently collaborates with CROs and smaller technology companies in the lead generation phase of drug discovery, adopting a medicinal chemistry approach to the development, synthesis and analysis of drug molecules and other bioactiv…