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Rani Therapeutics launches RT-111 development program

Robotic pill company Rani Therapeutics (Nasdaq:RANI) has begun developing RT-111, a RaniPill GO capsule containing a biosimilar of Johnson & Johnson’s (NYSE:JNJ) Stelara (ustekinumab).

The company anticipates that RT-111 could potentially treat psoriatic arthritis, ulcerative colitis, Crohn’s disease and psoriasis.

The FDA first approved Stelara in 2009 for psoriasis.

Stelara is available in intravenous and subcutaneous doses. It is most commonly administered subcutaneously.

“Ustekinumab has helped thousands of patients with inflammatory autoimmune diseases, but today the treatment requires regular long-term injections,” said Talat Imran, Rani CEO, in a news release.

The company hopes that RT-111 will reduce the treatment burden for ustekinumab candidates.

“We are increasingly excited about the potential of the RaniPill platform to provide patients with oral replacements to current injectable standards of care, and we expect that…

This CEO is swallowing his own devices to fund his swimming PillBot

Endiatx co-founder and CEO Torrey Smith with PillBot in his Oakland, California, workshop [Photo by Hardy Wilson for MDO]As he prepared to swallow his robot for the first time, Torrey Smith’s doctors warned that the battery was his greatest threat.

If the capsule came apart and the battery burned the tissue lining his stomach, it would only be the beginning of a very bad experience.

“I was just hoping that we would get any kind of a positive signal that we were on the right track,” Smith, co-founder and CEO of Endiatx, said of the June 2020 test. “At that time, our radio bandwidth was so limited. We were pushing 48 pixels square of grayscale, not even color, at just a few frames per second. The worst video quality you could imagine — but it was real.”

The PillBot prototype’s inaugural journey into Smith’s gastrointestinal tract was a success, beaming live footage from his stomach without anesthesia, sedation, recovery time or air pumped into his gut to infl…

Endiatx’s pill-sized robot sees and swims inside the stomach

Endiatx co-founder and CEO Torrey Smith with PillBot [Photo by Hardy Wilson for MDO]

An unconventional CEO and his team take aim at endoscopies with faster, cheaper stomach imaging — and that’s just the start. Welcome to the era of tiny robots inside the body.

As he prepared to swallow his robot for the first time, Torrey Smith’s doctors warned that the battery was his greatest threat.

If the capsule came apart and the battery burned the tissue lining his stomach, it would only be the beginning of a very bad experience.

“I was just hoping that we would get any kind of a positive signal that we were on the right track,” Smith, co-founder and CEO of Endiatx, said of the June 2020 test. “At that time, our radio bandwidth was so limited. We were pushing 48 pixels square of grayscale, not even color, at just a few frames per second. The worst video quality you could imagine —…