Cybin sees near future for psychedelic therapy after promising interim phase 2 data

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With promising interim phase 2 data in hand, Cybin believes psychedelic therapy will become a reality in the “not too distant future,” according to CEO Doug Drysdale.

As recently as the 1990s, it would be difficult to imagine that a psychedelic drug would potentially be a clinical option for a mood disorder like depression. But before long, data from multiple phase 3 trials will be available on psilocybin derivatives for various mood disorders.

Interim phase 2 CYB003 data as a ray of hope for treating mood disorders

Toronto, Canada–based Cybin recently unveiled upbeat interim phase 2 data related to CYB003, a proprietary deuterated psilocybin analog, in patients with moderate to severe major depressive disorder (MDD). In the randomized double-blind placebo-controlled study, CYB003 demonstrated a rapid and robust reduction in depression symptoms just three weeks …

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Delix Therapeutics launches phase 1 study for novel neuroplasticity-promoting therapeutic

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Boston-based Delix Therapeutics has won regulatory approval to commence a study of the non-hallucinogenic psychoplastogen DLX-001. Psychoplastogens are a class of drugs that have the potential to promote neuroplasticity, which refers to the brain’s ability to adapt and form new connections between neurons. That capability could enable improvements in conditions such as depression, anxiety and addiction.

DLX-001 offers potential for a range of conditions, according to Retsina Meyer, head of corporate strategy at Delix. “The aperture for indications for psychoplastogens is broad and is even broader for our non-hallucinogenic compounds of this class,” Meyer said. DLX-001 holds promise for conditions where cortical dendritic/synaptic atrophy plays a role in the pathology. Such atrophy is involved in conditions ranging from major depressive disorder (MDD), schizophrenia, Parkinson’s disease…

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