Axcella touts positive results from Phase 2a long COVID study

The biotech Axcella Therapeutics (Nasdaq:AXLA) has announced positive topline results from a Phase 2a randomized, double-blind, placebo-controlled study of the metabolism-modulator AXA1125 in patients with fatigue from long COVID.

The Phase 2a study was among the first drug studies to focus on long COVID.

In February, FDA granted a Fast Track Designation to AXA1125 to treat non-alcoholic steatohepatitis (NASH) with liver fibrosis.

Because of AXA1125’s potential to improve mitochondrial function, bioenergetics and inflammation, Axcella decided to study its ability to improve fatigue symptoms from long COVID. Fatigue is among the most common symptoms associated with long COVID.

Long COVID appears to be similar to post-viral fatigue syndrome and myalgic encephalitis.

Partnering with the University of Oxford, Axcella identified multiple endpoints to consider in studying AXA1125 in long COVID patients. Endpoints included phosphocreatine recovery…

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Study bolsters case that vaccines protect against long-COVID

A scanning electron microscope image shows SARS-CoV-2 (yellow). Credit: NIAID-RML

It may be too soon to know how often the omicron variant is associated with so-called long-COVID, but research from the Leavitt Partners’ COVID-19 Patient Recovery Alliance confirms that vaccination protects against the condition. 

Those who received at least one authorized COVID-19 vaccine dose before diagnosis were between seven and 10 times less likely to report two or more long-COVID-19 symptoms, according to the preprint study conducted before the surge of the delta variant. 

Those who received a vaccine four weeks after diagnosis were four to six times less likely to develop the condition.

There are limits to how well researchers understand the condition given the fuzziness of the definition of long-COVID and the continual emergence of SARS-CoV-2 variants, said Michael A. Simon, principal data scientis…

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