Eli Lilly and Company’s (NYSE:LLY) Phase 3 monotherapy ADvocate trials in atopic dermatitis (AD) found that the investigational interleukin 13 inhibitor lebrikizumab supported durable skin clearance and reduced itching in a subset of patients with atopic dermatitis.
The Indianapolis–based company defined responders as those with at least 75% improvement in the Eczema Area and Severity Index from baseline (EASI-75) or an Investigator Global Assessment of 0 or 1 (“clear” or “almost clear”) with a 2-point improvement at week 16 without rescue medication. The clinical trial re-randomized responders to receive lebrikizumab 250 mg every two weeks or four weeks or a placebo for 36 more weeks.
Lebrikizumab performed similarly in responders when dosed at a two- or four-week interval after week 16.
“Despite available treatment options, many patients with atopic dermatitis experience distressing symptoms every day over the course…