The popularity of CRISPR-based non-viral gene insertion techniques is fueling interest in CRISPR/Cas genome-editing technology that uses the homology-directed repair (HDR) pathway to insert DNA sequences.
To respond to that demand, biotech services firm GenScript has introduced GMP-compliant single-stranded DNA (ssDNA) and closed-end linear double-stranded DNA (dsDNA) services.
The company’s GenExact ssDNA services support up to 5000 nt in length and 100mg per batch production scale. GenWand services offer closed-end, linear dsDNA up to 10,000 nt in length and gram level/batch production scale.
Launching the services at the American Society of Gene & Cell Therapy annual meeting, Piscataway, New Jersey-based GenScript now boasts a range of non-viral HDR payload materials for early discovery research, process development and clinical trials.
The company said the offerings would also help facilitate CAR-T drug development.