The 50 best-selling pharmaceuticals of 2022: COVID-19 vaccines poised to take a step back

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The COVID-19 pandemic has had a profound impact on the best-selling pharmaceuticals, leading to shifts in the list with Pfizer and BioNTech’s Comirnaty surpassing AbbVie’s Humira for the No. 1 spot in 2021. That momentum continued in 2022, with Pfizer and BioNTech jointly raking in $59.1 billion in revenue from the sales of the COVID-19 vaccine. Although Comirnaty maintained its position as the best-selling pharmaceutical of 2022, it experienced a roughly 5% drop in sales compared to the previous year.

As the best-selling pharmaceuticals of 2022 demonstrate, signs are emerging that the reign of COVID-19 vaccines and  other therapies appears to be slipping.. The two companies — and Moderna — plan on hiking prices to address the weakening demand.

Humira: The second best-selling pharmaceutical of 2022 looking strong

Meanwhile, the heavyweight tumor necrosis factor (TNF) block…

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Regeneron’s Eylea approved for preterm infants with ROP, first drug treatment for condition

Regeneron Pharmaceuticals (Nasdaq:REGN) has received an indication for Eylea (aflibercept) injection for preterm infants with retinopathy of prematurity (ROP). 

The approval is the first pharmacologic treatment for the condition, which affects roughly 50% to 70% of infants with a weight less than 1250 grams (2.76 pounds) at birth. The condition is more common in infants born before 31 weeks of pregnancy. 

The condition is a common cause of childhood blindness. 

A growing number of indications

FDA first approved Eylea for wet age-related macular degeneration in 2011. Indications followed for diabetic macular edema, macular edema following retinal vein occlusion and diabetic retinopathy in patients with diabetic macular edema.

The approval is based on data from two global Phase 3 trials, FIREFLEYE and BUTTERFLEYE. The studies compared EYLEA to laser photocoagulation in infants with ROP. The data showed that approximately 80% of EYLEA-treated infants…

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