The pizza box problem — and why it might kill everything from Teflon to drugs

By Mark Jones

It looks innocuous in my hand, yet there are growing calls to ban it. It may use technology created for the Manhattan Project, but, in my hand, it doesn’t feel like a weapon. It feels natural, in spite of the very unnatural materials it may contain. I’m not at all cautious as I open it. Reaching in, I grab a slice. I do love pizza.

Pizza predates the Manhattan Project. Although pizza technically isn’t the problem, it’s the box. Cardboard for pizza boxes have been made resistant to both grease and steam using fluorocarbons. Five years ago, almost certainly, per- or polyfluorinated alkyl substances, PFAS, would have been used. Some states have now banned PFAS in things like pizza boxes. I’m not in one of those states. I can’t be sure whether the box in my hand uses PFAS or not.

PFASes were initially identified as a health concern at hotspots. There are many maps with marke…

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The pros and cons of membrane-based WFI generation and distillation for biopharma

Modern ambient water for injection (AWFI) generation system [Image courtesy of CRB]

The pharma industry is in the process of moving toward ambient water for injection (WFI).

Despite changes to regulations almost five years ago that allowed for alternative methods of generating WFI, the industry has been slow to fully embrace the shift away from traditional distillation despite the significant advantages of membrane-based WFI generation.

For companies with legacy distillation systems, the investment in new equipment for ambient WFI can be significant. Given its history, many pharmaceutical companies are familiar with the traditional distillation method.

In this article, industry experts from CRB, Chris Carlson and Jarrod Wrampe, describe the considerations to keep in mind when choosing between membrane-based WFI and traditional distillation for pharma applications.

Pro for membrane-based WFI …
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