Zepbound helps people lose 25% of body weight on average 88 weeks, but weight regain is a concern

Lilly’s hot weight loss drug Zepbound (tirzepatide) may be one of the most effective drug therapies for weight loss. In an open-label 36-week study, participants lost an average of 20.9% of their body weight in 36 weeks. With an average weight of 107.3 kg (236.5 lbs), that equates to about 22.4 kg (49.4 lbs) on average.

Weight regain a risk for those going off Zepbound

The catch, however, is that participants needed to keep taking the drug to keep losing weight. Those who stopped taking it saw a rebound, regaining about half of what was lost in the 52-week period after the initial 36-week study. But those who kept taking tirzepatide continued losing weight — an additional 5.5% reduction from week 36 to week 88.

In general, significant weight loss followed be regain can be more than an inconvenience. A Journal of Clinical Endocrinology and Metabolism 16-year prospective cohort study looking at patients with type 2 diabetes found such fluctuations to be linked to…

Read more
  • 0

Finding the right formula for nitrosamine risk mitigation 

[kseniyaomega/Adobe Stock]

The pharmaceutical industry is facing many challenges to ensure drug products are free from nitrosamine contaminants and safe for human use. Since the discovery of potentially carcinogenic nitrosamines in some commonly prescribed drug products in 2018, mitigating nitrosamine risk has been a top priority for the pharmaceutical industry and its governing bodies. As such, strict regulations have been implemented by the Food and Drug Administration (FDA) and European Medicines Agency (EMA) to assess and minimize the risk of nitrosamine impurities in existing and new drug formulations. However, navigating the new legislation and choosing a suitable mitigation strategy is a complex process.  

Navigating nitrosamine risk mitigation with confidence

Many research groups are investigating possible root causes of nitrosamine contamination in human drug products and potential mitigation strategies…

Read more
  • 0