GLP-1 drug tirzepatide shines in SURMOUNT-3 trial with weight loss of 26.6%

In the phase 3 SURMOUNT-3 trial, tirzepatide recipients saw some of the most impressive weight loss results among trials of GLP-1 drugs, including most notably semaglutide. In the study, participants’ total mean weight loss was 26.6% over 84 weeks following a 12-week intensive lifestyle intervention and subsequent tirzepatide treatment. In all, participants who received tirzepatide lost an additional 18.4% of their body weight compared to a weight gain of 2.5% in the placebo group.

In SURMOUNT-3, some 87.5% of participants who received tirzepatide achieved an additional weight reduction of 5% or more, compared to 16.5% of those in the placebo group.

While it is difficult to compare data from separate studies, the highest weight loss percentage for tizepatide, 26.6%, was 53% higher than the highest percentage, 17.4%, for semaglutide (OASIS 1).

google.charts.load('current', {packages: ['corechart', 'bar']}); google.charts.setOnLoadCallback(dr…
Read more
  • 0

Epstein-Barr virus: Trigger and driver of multiple sclerosis?

Microscopic view of the Epstein-Barr virus (EBV), stained with Hematoxylin and eosin (HE). This color image highlights abnormal cells or tissue associated with EBV, a virus linked to several types of cancer and other disorders. Source: National Cancer Institute.

Recent research has indicated a link between Epstein-Barr virus (EBV) and multiple sclerosis (MS), with some researchers going as far as to say that EBV might be a potential trigger of MS. However, it remains unclear whether the virus also drives the progression of the disease. Current treatments focus largely on moderating inflammation. In this article, we expand on the hypothesized correlation between MS and EBV, and underscore the need to consider antiviral protection in drug development.

Background

Multiple sclerosis. MS is an unpredictable and debilitating neurological autoimmune disease that turns the body’s immune system against itself, …

Read more
  • 0

A deep dive into AWS’s strategy with generative AI and ML in life sciences

[Image Fabrizio/Adobe Stock]

The AI market is witnessing meteoric growth, with projections hinting at a potentially staggering increase over the next decade. Against this backdrop of rapid AI evolution, we recently spoke with Tehsin Syed, general manager of AWS Health. Syed shared that Amazon Web Services (AWS) is seeing growing interest from Big Pharma firms. “Nine of the top 10 pharma companies in the world have a large majority of the workloads running on AWS,” Syed said. The AWS cloud hosts more than 100,000 customers across industries.

AWS aims to provide a broad and deep range of AI services and takes an end-to-end approach to AI that includes infrastructure, software, hardware and services.In an increasingly competitive AI landscape, AWS recently launched a $100 million initiative, the AWS Generative AI Innovation Center, to accelerate enterprise generative AI adoption. As Syed put it, “AWS has a pe…

Read more
  • 0