Draper develop gum tissue model with Colgate-Palmolive that could pave way for biomedical research advances

Draper’s MOUTH model

In collaboration with Colgate-Palmolive, organ-on-a-chip developer Draper has unveiled a gum tissue model that can sustain gum tissue viability for up to 28 days. The timeline far exceeded that of previous models. The research was featured in Communications Biology, an imprint of Nature.

Else Vedula, a senior researcher at Draper, described the gum tissue model as a significant improvement over conventional models, given its ability to mimic in vivo conditions. The platform opens new horizons for testing the efficacy of treatments for oral diseases, according to Vedula. “The MOUTH model contains 96 microtissues on one plate with a month-long culture window, enabling many conditions to be evaluated while studying tissue response to products and therapies,” she explained.

The MOUTH model’s ability to offer real-time sensing provides high-resolution, non-invas…

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Omics is helping unleash the utility of organ on a chip technology

Draper’s PREDICT-96 organ-on-a-chip system

Organ-on-a-chip technology, which simulates the function of an organ or an organ system, has steadily evolved over the past decade. 

The promise of the technology has evolved as well, said Timothy Petrie, head of strategy and business development, pharmaceutical R&D technologies at Draper (Cambridge, Mass). 

In the beginning, it seemed like the central appeal of organ-on-a-chip technology was to improve the efficiency of drug development. Some 90% of drug candidates fail during clinical development. Organ-on-a-chip technology promises to help drug developers more accurately how a drug will perform in humans. 

“With the advent of omics and Big Data applied to secretion and gene expression in proteins at a cellular level, you get a ton more information out of tissue,” Petrie said. That results in new possibilities for organ-on-a-chi…

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