Study combines biomimetic AI, digital twins and multiomics to unveil potential genetic drivers of endometriosis

The study developed a biomimetic digital twin ecosystem that tailors analysis to endometriosis research. This system integrates expert knowledge and raw clinical data to improve identification and analysis of molecular profiles linked to the disease. Image licensed under Creative Commons from The Journal of Molecular Diagnostics. https://doi.org/10.1016/j.jmoldx.2024.03.004, Figure 2.

Endometriosis, a condition where endometrial tissue grows outside the uterus, has a strong genetic underpinning. A new study published in the Journal of Molecular Diagnostics sheds light on this connection. Researchers from a team including Genzeva, LumaGene, RYLTI Biopharma, Brigham & Women’s Hospital of Harvard University and QIAGEN Digital Insights used a unique approach in their analysis of endometriosis patient samples. They combined multiple data sources, spanning multiomics data, next-generation sequencing, phenot…

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An inside look at GSK’s digital twin initiative

A GSK vaccine facility. Image courtesy of GSK.

Digital twins, functional computerized models of physical objects, are a staple of smart manufacturing. Their use in the pharmaceutical industry, however, is still in an early phase.

GlaxoSmithKline (LON:GSK) is one of the first pharmaceutical companies to announce a digital twin initiative. Partnering with Siemens (ETR:SIE) and Atos (EPA:ATO), GSK has created a real-time simulation of the entire vaccine manufacturing process.

A year in the making

The project, which launched a year ago, has already shown promise in reducing manufacturing timelines, optimizing product quality and other areas. The use of digital twins has enabled GSK to optimize vaccine-related experiments. “With digital twins, you’re able to do huge amounts of digital experiments and minimize the number of wet experiments that you do,” said Matt Harrison, head of sciences, digital innovati…

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