Tirzepatide beats semaglutide 3-to-1 for weight loss goals in real-world data

A new real-world study (pre-print) is the first to directly compare weight loss outcomes between the popular diabetes medications Lilly’s Mounjaro (tirzepatide) and Novo Nordisk’s Ozempic (semaglutide). The results show Mounjaro users are significantly more likely to achieve meaningful weight loss.

Analyzing data from more than 40,000 patients from a large U.S. health database, the researchers found those taking Mounjaro were nearly three times more likely to lose 10% of their body weight compared to Ozempic users. Additionally, they were also almost twice as likely to lose 5% of their weight, and three times more likely to lose 15%.

Weight Loss Thresholds Comparison google.charts.load('current', {'packages':['corechart']}); google.charts.setOnLoadCallback(drawChart); function drawChart() { var data = google.visualization.arrayToDataTable([ ['Drug', '≥5% Weight Loss', '≥10…
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An overview of the GLP-1 landscape in obesity therapeutics

[Feng Yu/Adobe Stock]

The GLP-1 drug market continues to boom lately thanks to highly effective new medications like Novo Nordisk’s Wegovy and continued demand for the drug class in diabetes. The runaway success of Wegovy and Ozempic (both formulations of semaglutide) has caused Novo Nordisk’s share price to skyrocket in 2023, briefly making the Danish pharmaceutical company the most valuable in Europe by market capitalization. Novo Nordisk’s growth has even exceeded Denmark’s entire economic output.

Far-ranging GLP-1 landscape projections

Given the massive potential of the obesity drug market, with projections ranging from Goldman Sachs’ $44 billion to Barclays’ $100 billion by 2030, Big Pharmas such as Novo Nordisk and Lilly are engaging in billion-dollar acquisitions of smaller biotechs with promising obesity pipelines.

At present, Novo Nordisk is having troubling ke…

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