Experts have theorized that mucosal vaccines, which could be administered nasally, orally or transdermally, could alter the trajectory of the pandemic. But a recent setback involving an intranasal version of AstraZeneca’s ChAdOx1 nCoV-19 COVID-19 has dampened those hopes.
A Phase 1 study published on Lancet’s eBioMedicine found that intranasal vaccination was detectable in a minority of participants. Intramuscular vaccination with the ChAdOx1 generally led to more robust systemic responses than the intranasal vaccine.
The open-label partially-randomized study did find that participants had antigen-specific antibodies after receiving an intramuscular mRNA vaccination following the administration of the intranasal vaccination.
The vaccine was well tolerated in the study.
Seven of the 42 volunteers in the t…