Oncolytic adenoviruses have won significant attention in recent years as a novel approach to cancer treatment. One example of the trend is AdAPT-001 TGF-ß Trap, an engineered variant of the common cold virus equipped with a transforming growth factor-beta (TGF-β) “trap.” This mechanism is designed to latch onto and neutralize TGF-β, an immunosuppressive cytokine involved in cancer cell growth and disease progression.
At the 2023 ASCO Annual Meeting, the developer of AdAPT-001, EpicentRx, shared initial findings from a phase 1 trial on AdAPT-001. The initial data indicates that patients generally tolerate AdAPT-001 well.
So far, the study has enrolled 28 patients for treatment with AdAPT-001 as a single agent. EpicentRx plans to enroll an additional roughly 50 patients for a phase 2 portion where AdAPT-001 will be combined with immunotherapy.
In the phase 1 por…