Pfizer Inc. (NYSE:PFE) is abandoning plans to develop an investigational antisense therapy known as vupanorsen for potential use for cardiovascular indications and severe hypertriglyceridemia (SHTG).
The company had projected that vupanorsen could generate up to $3 billion in peak sales.
Pfizer is returning development rights of the drug to Ionis Pharmaceuticals (NSDQ:IONS), from whom it licensed the drug in 2019.
“While this outcome is disappointing, the clinical and scientific knowledge derived from the vupanorsen program will hopefully contribute to a greater understanding of cardiovascular risk reduction and severe hypertriglyceridemia and the current gaps in treating these conditions,” said Dr. James Rusnak, senior vice president and chief development officer, internal medicine and hospital of Pfizer, in a statement.
Pfizer, which led the development of vupanorsen, made the decision after reviewing data from the global TRANSLATE-TIMI 70 Phase…