Sanofi oncology drug candidate hits roadblock

Amcenestrant, a once-promising investigational optimized oral selective estrogen receptor degrader (SERD) from Sanofi (Nasdaq: SNY), did not meet the primary endpoint in a recent Phase 2 trial focused on advanced or metastatic breast cancer.

Sanofi had previously referred to amcenestrant as a “potentially transformative” product.

Investigators did not identify any new safety signals for the drug candidate in the Phase 2 AMEERA-3 trial.

SNY initially dipped after the news was announced but had stabilized by the middle of the day — up 1.60% to $50.94.

Some 367 patients participated in the open-label study.

Sanofi plans to study amcenestrant in the upcoming AMEERA-5 and AMEERA-6 studies.

“This Phase 2 trial evaluated amcenestrant as a monotherapy in a patient population with advanced disease where limited treatment options remain,” said Dr. John Reed, head of research and development at Sanofi. “While we are disappointed with the AMEERA…

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