COVID-19 lung Hierarchical Phase-Contrast Tomography HiP-CT X-rays
HiP-CT provided a close-up of the lung lobe of a 54-year-old male COVID-19 victim. The image shows the airspaces in cyan, open blood vessels in red and blocked blood vessels in yellow. [Image courtesy of Paul Tafforeau, lead scientist at ESRF]

An international team has used super-bright X-rays to capture intricate details of COVID-19 lung damage — and much more.

Their technique — called Hierarchical Phase-Contrast Tomography (HiP-CT) — relies on X-rays from the European Synchrotron Research Facility particle accelerator in Grenoble, France. Following its Extremely Brilliant Source upgrade (ESRF-EBS), European Synchrotron can produce X-rays 100 billion times brighter than a hospital X-ray. They’re the brightest X-rays in the world, according to the researchers.

The result is that researchers can view blood vessels that are five microns in diameter — a tenth of the diameter of a hair — in an intact, donated human lung. The tiny size is 100 times smaller than the 1 mm-diameter blood vessels that a typical clinical CT scan can capture.

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